Collaborative Research Center SFB 645

The Collaborative Research Center SFB 645 “Regulation and manipulation of information flow within dynamic protein and lipid environments” is an interdisciplinary research initiative of the University of Bonn which is funded by the German Research Foundation (DFG) since January 2005. 20 research projects and 11 research institutes participate in the SFB 645. Recently, the second funding period from 2009-2012 was granted.

Key objectives of this initiative are to study the role of lipid metabolizing enzymes in controlling membrane composition and cellular metabolism, to analyse the dynamics and organization of membrane proteins and to elucidate the molecular mechanisms that control membrane trafficking. The research programme is composed of three project sections:

• Project Section A: "Biological and chemical modulation of membrane molecule function and dynamics"
• Project Section B: "Genetic and biochemical manipulation of the lipid metabolism for the analysis of membrane protein function"
• Project Section C: "Membrane Trafficking".