Collaborative Research Center SFB 645

Members & Projects

Project Section A:
Biological and chemical modulation of membrane molecule function and dynamics

No.	Title	Research area	PI, Institute
A1	Membrane-proximal signalling events in migrating immune cells	Cell biology, immunology	Prof. Dr. W. Kolanus, LIMES-Institute, Molecular Immunology, Bonn
A3	Novel inhibitors of cytoplasmic transmembrane domains and membrane-associated signalling molecules and their use in functional analysis	Chemical Biology, Molecular Biomedicine, Biochemistry	Prof. M. Famulok, LIMES Insitute Chemical Biology & Medicinal Chemistry, Bonn
A4	Regulation of membrane trafficking and organization by the Liprin-α protein family	Molecular Neurobiology	Dr. S. Schoch-McGovern, Institute of Neuropathology, Bonn
A7	γ-Secretase dependent transport of lipoprotein receptors	Alzheimer’s disease	Prof. J. Walter, Department of Neurology, University Hospital, Bonn
A9	Non-Genomic Action of Progesterone	Biophysics, Sensory Physiology	Prof. B. Kaupp, Center of European Studies and Research (caesar), Bonn
A10	Molecular mechanisms and functional aspects of insulinreceptor clustering	Membrane molecule dynamics	Prof. T. Lang, LIMES Institute, Membrane Biochemistry, Bonn

 

Project Section B:
Genetic and biochemical manipulation of the lipid metabolism
for the analysis of membrane protein function

No.	Title	Research area	PI, Institute
B1	Role of Schlank in linking cellular lipid synthesis with hormonedependent body fat metabolism	Lipid Metabolism	Dr. Reinhard Bauer, Prof. Dr. Michael Hoch LIMES-Institute Development & Genetics, Bonn
B2	Biological consequences of mutations in sphingolipid biosynthesis on metabolism growth control, cell adhesion and ion channels in transgenic mice	Molecular Genetics	Prof. K. Willecke, Inst. of Genetics/ LIMES Institute, Bonn
B3	Function of lysosomal lipid binding proteins (Previous title: Functional analysis of membrane lipids in mutant cell lines)	Lipid and Membrane Biochemistry	Prof. K. Sandhoff, LIMES, Membrane Biology & Lipid Biochemistry Unit, Bonn
B5	Role of 2-hydroxylated sphingolipids in the nervous system and skin	Biochemistry	Dr. M. Eckhardt, Prof. V. Gieselmann, Institute of Physiological Chemistry, Bonn
B7	Endocannabinoids: Metabolites of Phospholipids as Modulators of Cell Function	Cell signalling	Prof. A. Zimmer, Institute of Molecular Psychiatry, Bonn Prof. I. Bab, Bone Laboratory, Jerusalem
B8	Regulation of lipid synthesis in plant membranes	Plant lipid biochemistry	Prof. P. Dörmann, IMBIO, Bonn
B9	Pathophysiological role of bile acid β-glucosidase (GBA2): Studies with GBA2-deficient mice, mutation analysis of Gaucher patients	Sphingolipidmetabolism, Genetics, Liver regeneration, Neuroprotection	Dr. Y. Yildiz, Internal Medicine I, Bonn v. Echten-Deckert, LIMES, Membrane Biology & Lipid Biochemistry, Bonn

 

Project Section C:
Membrane Trafficking

No.	Title	Research area	PI, Institute
C1	Molecular mechanisms of mannose-receptor-mediated endocytosis into stable early endosomes	Immunology, Cellbiology	Prof. C. Kurts, IMMEI, Bonn
C2	Cell-free Analysis of Phagosome Biogenesis in Macrophages	Molecular Cell Biology	Prof. A. Haas, Institute of Cell Biology, Bonn
C3	Analysis of the novel multidomain protein p86DM: coordination of endocytosis, recycling and cytoskeletal organization	Membrane trafficking	Prof. T. Magin, Institute of Physiological Chemistry, Bonn
C4	Insulin/insulin receptor transport and endocytosis in Drosophila neuroendocrine cells	Membrane trafficking	Prof. M. Pankratz, LIMES Institute, Development & Genetics, Bonn
C5	Role of the novel J-domain transmembrane protein wurst in the regulation of clathrinmediated endocytosis	Genetics, Cell biology, Molecular Biology	Dr. Matthias Behr Prof. Dr. Michael Hoch LIMES Institute Development & Genetics, Bonn
Z2	Central services		Prof. Dr. Michael Hoch LIMES Institute Development & Genetics, Bonn
Z3	Transgenic animals (generation and housing in the LIMES animal facility)	Technical Support	Dr. Joachim Degen, Inst. of Genetics/ LIMES Institute, Bonn

 

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